Diffusion through a cluster of small windows and flux regulation in microdomains
نویسندگان
چکیده
The way the arrangement of small conductors of ionic current on biological membranes regulates flux is an open physical question. We study this problem by a model of diffusion through a cluster of channels in an impermeable biological cell membrane. We show that the flux depends on the relative distance between the channels and show that moving two contiguous channels apart may increase the flux by nearly 50%. Brownian simulations in 2 and 3 dimensions agree with the theoretical results. © 2008 Elsevier B.V. All rights reserved.
منابع مشابه
Diffusion escape through a cluster of small absorbing windows
Abstract We study the first eigenvalue of the Laplace equation in a bounded domain in R (d = 2, 3) with mixed Neumann–Dirichlet (Zaremba) boundary conditions. The Neumann condition is imposed on most of the boundary and the Dirichlet boundary consists of a cluster of small windows. When the windows are well separated the first eigenvalue is asymptotically the sum of eigenvalues of mixed problem...
متن کاملComparison of heat loss and air infiltration through the openings of Qajar and Pahlavi era houses in Tabriz
The rapidly growing world energy use has already raised concerns over energy resources and greenhouse gas (GHG) emissions. Since the global contribution from residential buildings towards energy consumption, has steadily increased between 20% and 40% and as large openings have considerable energy and heat loss in dwellings, this paper establishes a coefficient of heat loss and air infiltration ...
متن کاملInfluence of Chemical Permeation Enhancers on the in vitro Skin Permeation of Minoxidil through Excised Rat Skin: A Mechanistic Study
Abstract: Minoxidil, a pyrimidine derivative (2, 4-diamino-6-piperidinopyrimidine-3-oxide) is the only topical medical treatment with proven efficacy for the treatment of Androgenetic alopecia that shown low skin penetration and bioavailability. The main aim of this research was to investigate the effect of some permeation enhancers on the in vitro skin permeability of minoxidil . Minoxid...
متن کاملEnhancement of Toxic Substances Clearance from Blood Equvalent Solution and Human Whole Blood through High Flux Dialyzer by 1 MHz Ultrasound
Background: Hemodialysis is a process of removing waste and excess fluid from blood when kidneys cannot function efficiently. It often involves diverting blood to the filter of the dialysis machin to be cleared of toxic substances. Fouling of pores in dialysis membrane caused by adhesion of plasma protein and other toxins will reduce the efficacy of the filtre.Objective: In This study, the infl...
متن کاملA Modified Flux Vector Splitting Scheme for Flow Analysis in Shock Wave Laminar Boundary Layer Interactions
The present work introduces a modified scheme for the solution of compressible 2-D full Navier-Stokes equations, using Flux Vector Splitting method. As a result of this modification, numerical diffusion is reduced. The computer code which is developed based on this algorithm can be used easily and accurately to analyze complex flow fields with discontinuity in properties, in cases such as shock...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008